Heterologous Expression of Hybrid Ytpe II Polyketide Synthase System in Streptomyces Species
2003
Kim, C.Y. | Park, H.J. | Kim, E.S. (Inha University, Incheon, Republic of Korea)
Polyketides are an extensive class of secondary metabolites with diverse molecular structures and biological activities. A plasmid-based minimal polyketide synthase expression casstte was constructed using a subset of actinorhodin biosynthetic genes from Strptomyces coelicolor, which specify the construction of an orange-fluorescent anthraquinone product aloesaponarin II, a type II polyketide compound derived from one acetyl coenzyme A and 7 malonyl coenzyme A extender units
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