Antifungal activity of the crude extracts of Alafia barteri Oliver (Apocynaceae) and Chasmanthera dependens Hochst. (Menispermaceae)
2002
Adekunle, A.A. | Okoli, S.O. (University of Lagos (Nigeria). Dept. of Botany and Microbiology)
The antifungal properties of ethanol and water extracts of the leaves of Alafia barteri and the roots of Chasmanthera dependents were investigated individually using disc diffusion agar method. The phytochemical properties of the extracts were also assayed. The ethanol water crude extracts of the plants showed definite antifungal activity against Aspergillus flavus, A fumigatus, A niger, Candida albicans, microsporum audonii, Trichoderma viride and Trichophyton mentagrophytes. The ethanol extracts of the plants were more active than their respective water extracts. The extracts had varying zone of inhibition on each of the fungus. The ethanol extracts of Mafia barteri had the highest zone of inhibition of 27.42 plus-minus 0.70 mm. The antibiotics, Nystatin, was significantly (p = 0.01) more active than the plant extract on most of the fungi, except the ethanol extract of Alma barteri which was insignificantly more active on Aspergillus niger, at 10 mug/ml concentration. The crude extracts (ethanol and water) of the two plants contained flavonoids. Tannin was not present in the water extracts of C. dependents, while steroid was absent in the ethanol extract of A. barteri but present in the other extracts. Anthraquinone, Phylobatanin and Sponin were absent in the plant extracts. The significance of these results was discussed.
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