Pathological study of chronic swine fever in experimental pigs
1998
Tuangthong Patchimasiri | Wasana Pinyochon | Sudarat Damrongwatanapokin (Department of Livestock Development, Bangkok (Thailand). National Institute of Animal Health)
Three groups of 27 three-four-week old experimental pigs were divided into group 1 (9 seropositive to swine fever virus (SFV) pigs), group 2 (9 seronegative to SFV pigs) and control group (9 seronegative to SFV pigs). Eighteen pigs of group 1 and 2 were inoculated intranasally with low virulent swine fever virus strain Kampangpetch 1/1993 10*[6.5) TCID50/animal, meanwhile 9 pigs in control group received only tissue culture midium. One of inoculated pigs (group 1 and 2) and control pigs were necropsied on 1, 3, 6, 9, 12, 15, 18, 21 and 24 weeks post inoculation (WPI). The clinical signs and pathological findings were not different between group 1 and 2. Such findings were intermittent fever (15/18), skin lesion (16/18), mild non-suppurative encephalitis (12/18), mild to moderate depletion of lymphocytes in tonsil, spleen, lymph nodes and Peyer's patches (18/18, 15/18, 17/18 and 18/18), cellular depletion in bone marrow (13/18) and glomerulonephritis, arterial degeneration and hemorrhages in kidneys (8/18, 3/18 and 5/18). No changes were observed in control pigs. These against low virulent strain of SFV. In addition, the pathological changes from this observation will be very useful for confirmation of chronic fever.
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