Antinociceptive and antipyretic effects of Leea rubra root extract in experimantal animals
1998
Wantana Reanmongkol | Sanan Subhadhirasakul | Gulinda Udompat | Jarawee Suwankong | Jinda Chokwiwatanachai | Jirapan Thongprecha (Prince of Songkla Univ., Songkhla (Thailand). Faculty of Pharmaceutical Sciences. Dept. of Clinical)
Effects of the methanol extract of Leea rubra roots Blume (L. rubra) on nociceptive response using writhing, hot plate and formalin tests, and on pentobarbital-induced sleep in mice and the antipyretic activity of the extract in yeast-induced fever in rats, were examined. L. rubra extract (100-400 mg/kg, p.o.) dose-dependently decreased the number of contortions and stretchings induced by acetic acid but not in the heat-induced pain. At the same dose range, in the formalin test, the extract significantly reduced the duration of licking in the late phase but not in the early phase. The extract significantly reduced fever induced by yeast only at the high dose of 400 mg/kg. The L. rubra extract had no significant effect on pentobarbital-induced sleep. These results suggest that the L. rubra extract possesses peripheral antinociceptive and mild antipyretic effects and that the former effect seems to be involved in its anti-inflammatory action.
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