Study of anti-inflammatory activity of Randia siamensis Criab. in rats
1999
Chutinath Harnchariyakul | Supaporn Prasettho | Nisita Bumrungwong | Methi Sanbhanich (Prince of Songkla Univ., Songkhla (Thailand). Faculty of Science. Dept. of Pharmacology)
Anti-inflammatory activity of the medicinal plant, Randia siamensis Criab., was studied using the model of the carrageenan foot edema test in rats. The effects of crude water extract of this plant were studied by compared with those of prednisolone and ibuprofen. The substances were administered orally 1 hour prior to carrageenan injection and the paw edema inhibition was measured at 3 hours after carrageenan injection. The plant extract at the doses of 5, 10 and 50 mg/kg inhibited paw edema by 20.45, 36.36 and 59.09 percent, respectively, whereas the inhibition produced by prednisolone (5 mg/kg) and ibuprofen (10 mg/kg) were 50.09 and 47.73 percent respective. The result suggests that Randia siamensis Criab. in the form of crude water extract possibly possesses an anti-inflammatory activity and further investigation of other actions related to anti-inflammatory should be simultaneously studied.
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