Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: I.
1991
Kweifio-Okai, G.
A boiling water extract from a powdered sample containing Alstonia boonei root bark (90%), Rauvolfia vomitoria root bark (5%) and Elaeis guineensis nut without pericarp (5%) was tested intraperitoneally for its antiinflammatory activity by measuring rat hind-paw oedema induced by the subplantar injection of carrageenin in the presence or absence of arachidonic acid. Arachidonic acid increased swelling during the early phase of carrageenin oedema. The extract suppressed the late phase of carrageenin oedema and both phases in the presence of arachidonic acid. These preliminary results are consistent with a herbal preparation known to be used in Ghana in the management of rheumatoid arthritis.
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