Isolation and characterization of two protein isoforms with antiviral activity from chenopodium album L leaves
2003
Dutt, S. | Narwal, S. | Kapoor, H.C. | Lodha, M.L. (Indian Agricultural Research Institute, New Delhi (India). Division of Biochemistry)
Two antiviral proteins (AVPs) named CAP-I and CAP-II isolated and purified from the leaves of Chenopodium album cv Pusa Bathua 1 were found to inhibit tobacco mosaic virus (TMV) and sunhemp rosette virus (SRV) infection on their respective host plants. The molecular weight of both the AVPs was found to be 24 kD. They were devoid of carbohydrate moiety and were highly basic with pl ~10.2. However, they differed with respect to amino acid composition and N-terminal sequence. They also differed with respect to IC50 values, and CAP-I was found to be 2.5 fold more effective than CAP-II in inhibiting viral infection.
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