Antimutagenic activity against trp-p-1 of the edible Thai plant, Oroxylum indicum Vent
2001
Nakahara, K. (Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki) | Onishi Kameyama, M. | Ono, H. | Yoshida, M. | Trakoontivakorn, G.
A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC sub50 value of 2.78+-0.15microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.
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