Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice
2002
Hashimoto, T. (Kobe Univ. (Japan)) | Nonaka, Y. | Minato, K. | Kawakami, S. | Mizuno, M. | Fukuda, I. | Kanazawa, K. | Ashida, H.
To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrolne P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to felnale BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.
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