Effect of intracerebroventricular infusion of urocortin on feed and salt intake in parotid fistulated sheep
2002
"Sunagawa, K. (University of Melbourne, Victoria (Australia)) | McKinley, M.J. | Purcell, B.S. | Thomson, C. | Burns, P.L. "
"The effect of a new peptide, brain urocortin (UCN), in the central regulation of feed and salt intake in parotid fistulate sheep was investigated through a continuous intracerebroventricular (ICV) infusion of the peptide at a small dose for 48 I Feed and salt intake on day 1 of UCN infusion were similar to those before infusion. However, feed and salt intake on d< 2 during UCN infusion decreased significantly. Water intake on days 1 and 2 during UCN infusion was the same as th; before infusion. Saliva secretion from the unilateral parotid gland during UCN infusion was unchanged from that before infusion. On the other hand, urine excretion during UCN infusion increased significantly. The present results suggested th. UCN acts directly on the brain mechanisms of sheep to decrease feed and salt intake, but does not alter water intake."
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