Long-term clinical remission in response to glucocorticoid therapy in a Chihuahua with granulomatous meningoencephalitis
2004
Kotani, Y. (Hokkaido Univ., Sapporo (Japan)) | Yamato, O. | Ochiai, K. | Yamasaki, M. | Maede, Y.
SUMMARY Glucocorticoid therapy resulted in long-term c]clinical remission in a 4-year-old female Chihuahua with grinanomalous meningoencephalitis. A 2-week therapy regimen using dexamethasone improved such initial neurological symptorns as ataxia, tetraplegia, spasticity in the right side of body, leftward head-tilt, and nystagmus.Subsequent oral administration of prednisone (0.2-0.5 mg/kg every other day) sustained clinical remission for 2 and a half years. But severe motor dysfunction, seizures, occurred 2 years and 8 to 9 months after the start of therapy. Poor prognosis ultimately led to humane euthanasia. Pathological examination revealed reduction of the left cerebellar hemisphere accompanied by marked meningeal thickening. On the basis of histopathological features, the dog's condition was diagnosed as disseminated granulomatous meningoencephalitis.
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