Caffeic acid feeding of pregnant and lactating mice influences the immune response of their progeny
Skopinska-Rozewska, E. | Chorostowska-Wynimko, J. | Radomska-Lesniewska, D.(National Institute of Tuberculosis and Lung Diseases, Warsaw (Poland)) | Skopinski, P.(Medical University, Warsaw (Poland). Dept. of Histology and Embryology Biostructure Center) | Siwicki, A.(University of Warmia and Mazury, Olsztyn (Poland). Dept. of Microbiology and Clinical Immunology)
The aim of the present study was to examine the cellular and humoral immune response in the group of offsprings from mothers treated with caffeic acid (1 or 6 mg/day) during pregnancy and lactation. We observed that the mean spleen relative weight was reduced in 4-week old progeny of mice treated with 6 mg/day of caffeic acid. The percentage of spleen CD3+ lymphocytes was decreased in both examined doses, while the number of CD19+ lymphocytes was not affected. Local G-v-H reaction induced by splenocytes from 4-week old progeny of caffeic acidtreated mothers was significantly suppressed in both dosage groups. Caffeic acid feeding (6 mg) resulted in up-regulation of the peripheral blood granulocytes chemiluminescent activity as well as in the enhancement of anti-SRBC antibody production in the 6-week old progeny of the treated mothers. We concluded that caffeic acid-enriched mothers diet may affect progeny immune system function in the postnatal period
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Central Agricultural Library