Plasma ceruloplasmin and fibrinogen during enzyme therapy of mastitis in dairy cows
2006
Bakes, J.(Podripska Nemocnice s Poliklinikou, Roudnice nad Labem (Czech Republic). Nemocnicni Lekarna) E-mail:[email protected] | Illek, J.(Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Prezvykavcu)
The aim of this study was to demonstrate the benefits of topical administration of proteolytic enzymes used in the symptomatic mastitis therapy. Eleven lactating cows with clinical signs of mastitis were divided into two groups and administered intramammary cefotaxime as follows: group A 250 mg, 6 doses in total; group B 100 mg, 5 doses in total. In addition, the group B received a blend of enzymes. Before the beginning of the therapy, common mastitis pathogens were detected in milk of both groups; after the therapy, the results were negative. Mean plasma concentrations of fibrinogen and ceruloplasmin increased significantly from 6.0 to 7.4 g/L and from 0.9 to 1.3 micromol/L, respectively, in group A, whereas a non-significant decrease of both components was observed in group B. A favourable effect of repeated topical application of a mixture of proteolytic enzymes was demonstrated. The enzyme therapy resulted in a decreased therapeutic dose of the antibiotic, and suppressed an increase in the levels of inflammation markers.
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