Ability of CD8+ T cell anti-feline immunodeficiency virus (FIV) activity and FIV proviral DNA load in mononuclear cells in FIV-infected cats
2005
Hohdatsu, T. (Kitasato Univ., Towada, Aomori (Japan). School of Veterinary Medicine and Animal Sciences) | Nakanishi, T. | Saito, I. | Koyama, H.
We investigated the relationship between CD8+ T cell anti-feline immunodeficiency virus (FIV) activity and FIV proviral DNA load integrated in mononuclear cells. The anti-FIV activity and the proviral DNA load were correlated, and the number of proviral DNA copies was high in cats with decreased anti-FIV activity. Particolarly. no arni-FIV activity was detected in the cats staged as having an acquired immunodeficiency syndrome (AIDS)-related complex or AIDS, and the number of proviral DNA copies was obviously increased compared to those in the cats in the asymptomatic stage. These results suggest that decreased anti-FIV activity destroys the control of in viva FIV replication, which leads to an increased proviral DNA load with the progression of the clinical stage of disease.
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