Nutritional restriction in utero programs postnatal muscle development in lambs
2005
Tygesen, M.P.(Royal Veterinary and Agricultural Univ., Copenhagen (Denmark)) | Harrison, A.P.
The effect of nutritional programming during late gestation on evoked compound muscle action potentials (CMAP) during early postnatal life was examined. Lambs were born to ewes that were fed either an adequate or low nutrient supply during the last trimester of gestation. Lambs were born to either a ram with a high genetic potential for daily live weight gain, or a ram with a high genetic potential for both daily gain and lean content. CMAP signals were evoked by electrical stimulation and recordings were analyzed in terms of area, amplitude, width at 50% maximal height and both leading and trailing slopes. Significant effects of nutrient restriction during late gestation were measured for lamb birthweight, bodyweight at day 21 and growth rate (P0.001), as well as CMAP area, corrected peak and slope for Musculus longissimus dorsi at day 21 and as early as day 10 for Musculus biceps femoris. In conclusion, nutrient restriction during the last trimester of gestation influences evoked CMAP signal parameters postnatally in a muscle-specific fashion, and muscle development may be related to paternal genetic background.
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