Search of the infections source of feline calicivirus in a multicat household
2005
Ohe, K.(Azabu Univ., Sagamihara, Kanagawa (Japan). School of Veterinary Medicine) | Sakai, S. | Sunaga, F. | Murakami, M. | Kiuchi, A. | Furuyama, K. | Hara, M. | Soma, T. | Ishikawa, Y. | Taneno, A.
A multicat household experienced an epidemic of feline calicivirus (FCV) infection. FCV was isolated from eight of 34 cats. We analyzed molecular evolution of isolated FCVs by a phylogenic tree. All the isolates belonged to the genogroup II, and their nucleotide sequences showed 94% identity. They were subdivided into six distinct clusters by phylogenetic analysis, and Ao 198-1, the source of infection, was most closely related to Ao199- 1, then Ao212-1. Ao210-1, Ao214-1, Ao213-1, Ao222-1and Ao224-1 in this order. Sequence alignments of the isolates showed that the nonsynonymous substitution/total number of nucleotides ratio was 60% in the regions A, B, D conE and F, and 80% in the regions C and 5' and HVR of E. Our result suggested that the virus, while its transmission to the newborn cats, underwent frequent mutation especially at the regions C and E, suggesting these regions were most often involved in evolution of the FCV genome.
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