D-psicose inhibits intestinal alpha-glucosidase and suppresses glycemic response after carbohydrate ingestion in rats
2006
Matsuo, T.(Kagawa Univ., Miki (Japan). Faculty of Agriculture) | Izumori, K.
D-Psicose is one of rare sugars present in small quantities in commercial carbohydrates and agricultural products. In this study, we investigate the effects of D-psicose on the activities of a-amylases and a -glucosidases in vitro, and evaluate the effects of D-psicose on postprandiai glycemic response using rats in vivo. In vitro study, D-psicose potently inhibited intestinal sucrase and maltase, however, slightly inhibited intestinal and salivary a -amylase activities. Male Wistar rats (6 months old) were administrated 2 g/kg of sucrose, maltose or soluble starch together with 0.2 g/kg of D-psicose or D-fructose. D-Psicose significantly inhibited the increment of plasma glucose concentration induced by sucrose or maltose. Starch-induced glycemic response tended to be suppressed by D-psicose, however the suppression was not significant. These results suggest that D-psicose inhibits intestinal sucrase and maltase activities in an uncompetitive manner and suppresses the plasma glucose increase after sucrose and maltose ingestion. Thus, D-psicose may be useful in preventing postprandial hyperglycemia in diabetic patients when foods containing sucrose and maltose are ingested.
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