In vitro chromosome aberration test and in vivo micronucleus test of Ca-type garcinia extract
2006
Ono, H.(Nippon Shinyaku Co. Ltd., Kyoto (Japan)) | Tamura, H. | Yamashita, Y. | Tamura, K. | Iwakura, K.
The induction of chromosome aberration of Ca-type Garcinia cambogia extract containing about 65% (-)-hydroxycitric acid was investigated by use of the chromosome aberration test in cultured Chinese hamster lung cells (CHL/IU) and the micronucleus test in mice. In the chromosome aberration test, Ca-type Garcinia cambogia extract did not increase the number of cells with structural aberration and/or numerical aberrations. The micronucleus test was carried out with bone marrow cells of Slc : ddY male mice after single oral administration of up to 2,000 mug/kg. There was no significant increase in the frequency of micronucleated polychromatic erythrocytes. These results indicate that Ca-type Garcinia cambogia extract does not induce chromosome aberration.
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