Effect of Bu-Zhong-Yi-Qi-Tang on Proliferation of T Cells
Chae, S.Y.;Shin, S.H.;Ha, M.H.;Yee, S.T.(Sunchon National University, Suncheon, Republic of Korea)E-mail:sungtae@sunchon.ac.kr | Jo, S.K.;Byun, M.W.(Korea Atomic Energy Research Institute, Daejeon, Republic of Korea) | Kim, S.H.(Chonnam National University, Gwangju, Republic of Korea)
Bu-Zhong-Yi-Qi-Tang extracts is a traditional oriental medicine in a mixture type exhibiting strong anti-bacterial, analgesic, and chemopreventive activities. In this study, we have evaluated effects of the total and polysaccharide fraction of Bu-Zhong-Yi-Qi-Tang extracts on the T cell proliferation, cytokine production, and induction of IL-2 receptor and MHC class Ⅱ. For this experiment, we established CD4+ CD8- T cell line producing IL-2 and IFN-γ when stimulated with ovalbumin antigen in the presence of antigen presenting cells. The significant effect of Bu-Zhong-Yi-Qi-Tang on antigen-induced T cell proliferation in the presence of antigen presenting cells was observed.
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