Inhibitory effect of propofol on endothelium-dependent relaxation and blood pressure lowering in rats
Kim, S.J.;Kim, J.G.;Joe, S.G.;Kang, H.S.;Kim, J.S.(Chonbuk National University, Jeonju, Republic of Korea)E-mail:kimjs@chonbuk.ac.kr
We studied the effect of propofol (PPF) on the endothelium-dependent vascular responses in isolated rat thoracic aorta. In aortic rings with endothelium, PPF inhibited the phenylephrine (PE)-induced contraction in a concentration-dependent manner. In PE-precontracted preparations, PPF attenuated the endothelium-dependent relaxation by acetylcholine but not by A23187. And PPF did not attenuate the endothelium-independent relaxation by sodium nitroprusside (SNP).
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