Inhibitory effects of xylamine on the arterial contraction in rats
Kim, S.J.;Kang, H.S.;Kim, J.S.(Chonbuk National University, Jeonju, Republic of Korea)E-mail:kimjs@chonbuk.ac.kr
The therapeutic efficacy of xylamine in the field of psychological medicine has been recognized for years and the drug is used to treat depression and some other conditions, but little is known about its mechanism of action on vascular system. Therefore, the present study was designed to investigate the influence of xylamine on the contractile responses of isolated rat thoracic arteries to phenylephrine(PE) and potassium chloride(KCl). Xylamine produced a concentration-dependent relaxation in PE-precontracted endothelium intact(+E) rat aortic rings, but not in a KCl-precontracted aortic rings.
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