Efficacy of rifampin and streptomycin in Sprague-Dawley rats infected with Brucella abortus
Baek, B.K.;Choi, C.K.;Lim, C.W.;Lee, J.H.(Chonbuk National University, Jeonju, Republic of Korea)E-mail:baekbk@chonbuk.ac.kr | Kim, B.S.(Sohae College, Kunsan, Republic of Korea) | Lee, S.I.(Toyama Medical and Pharmaceutical University, Toyama, Japan) | Hur, J.;Kakoma, Ibulaimu(University of Illinois, Urbana IL., USA)
This study was carried out to investigate the efficacy of rifampin with or without streptomycin in male Sprague-Dawley (SD) rats experimentally inoculated with Brucella abortus. Thirty rats were intraperitoneally inoculated with 1.0×10∨9 colony-forming units of B. abortus. They were divided into 3 groups by treatment with antibiotic. 10 rats in Group A were orally administrated with rifampin, 10 rats in Group B with rifampin orally and with streptomycin intramuscularly over 12 weeks starting at 1 week post infection (PI).
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