Effects of Dietary Chitosan on Blood and Tissue Levels of Lead, Iron, Zinc, and Calcium in Lead Administered Rats
2005
Park, J.R. (Seoul National University, Seoul, Republic of Korea) | Lee, Y.S. (Seoul National University, Seoul, Republic of Korea), E-mail: [email protected]
Chitosan, which is a biopolymer, composed of glucosamine units linked by β-1, 4 glycoside bonds, is rich in shells of crustacean such as crabs and shrimps. We examined effects of dietary chitosan on blood and tissue levels of lead, iron, zinc and calcium in lead administered rats. Male Sprague-Dawley rats were divided into 4 groups (n=32). Basal diet group was fed 3% cellulose diet and lead administered groups were fed 0%, 3% and 5% chitosan diets, respectively for 8 wks. To lead administered groups, lead (20 mg/day) was given three times per week by oral injection. Blood, liver, kidney and femur were collected for lead, iron, zinc, and calcium analyses.
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