Differential Alterations of Endotoxin-induced Cytokine Expression and Mitogen-activated Protein Kinase Activation by Mercury in Mouse Kidney
2004
Kim, S.H. (Chosun University, Gwangju, Republic of Korea) | Kim, D.K. (Woosuk University, Wanju, Republic of Korea) | Choi, C.H. (Chosun University, Gwangju, Republic of Korea), E-mail: [email protected] | Shin, T.Y. (Woosuk University, Wanju, Republic of Korea)
The present study was designed to determine the impact of mercury on endotoxin-induced inflammatory cytokine expression and corresponding signal transduction in mouse kidney. Male BALB/c mice were exposed continuously to 0, 0.3, 1.5, 7.5, or 37.5 ppm of mercury in drink-ing water for 14 days and at the end of the treatment period, lipopolysaccharide (LPS, 0.5 mg/kg) was injected intraperitoneally 2 h prior to euthanasia. The doses of mercury and LPS did not cause hepatotoxicity or renal toxicity as indicated by unaltered plasma alanine aminotransferase and aspartate aminotransferase levels, and terminal UTP nucleotide end-labeling assay from kidney, respectively.
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