Effects of (1R,9S)-β-hydrastine hydrochloride on L-DOPA-Induced Cytotoxicity in PC12 cells
2004
Yin, Shou Yu (Chungbuk National University, Cheongju, Republic of Korea) | Lee, J.J. (Chungbuk National University, Cheongju, Republic of Korea) | Kim, Y.M. (Chungbuk National University, Cheongju, Republic of Korea) | Jin, Chun Mei (Chungbuk National University, Cheongju, Republic of Korea) | Yang, Y.J. (Chungbuk National University, Cheongju, Republic of Korea) | Lee, M.K. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: [email protected]
Previously, (1R,9S)-β-hydrastine hydrochloride has been found to lower dopamine content in PC12 cells (Kim et al., 2001). In this study, the effects of (1R,9S)-β-hydrastine hydrochloride on L-DOPA-induced cytotoxicity in PC12 cells were investigated. Treatment with (1R,9S)-β-hydrastine hydrochloride at concentrations higher than 500 μM caused cytotoxicity in PC12 cells. In addition, (1R,9S)-β-hydrastine hydrochloride at non-cytotoxic or cytotoxic concentrations significantly enhanced L-DOPA-induced cytotoxicity (L-DOPA concentration, 50 μM).
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