Antioxidant Activity of Rhodiola rosea Extract on Human Low-density Lipoprotein Oxidation and DNA Strand Scission
2004
Lee, E.J. (Hannam University, Daejeon, Republic of Korea) | Kwon, Y.I. (University of Massachusetts, Amherst, MA, USA) | Jang, H.D. (Hannam University, Daejeon, Republic of Korea), E-mail: haedong@hannam.ac.kr | Shetty, Kalidas (University of Massachusetts, Amherst, MA, USA)
Water and 75% ethanol extracts of Rhodiola rosea were investigated for reactive oxygen-scavenging activity, metal-chelating activity, and reduction power. The 75% ethanol extract showed higher 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical- and superoxide anion radical-scavenging activities than water extract. Hydroxyl radical-scavenging activities (IC∧50) of water and 75% ethanol extracts were 1.1 and 1.8 mg/mL, respectively, indicating water extract scavenged hydroxyl radicals produced through Fenton reaction more efficiently than 75% ethanol extract due to hydrophilic property of flavonoid in water extract.
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