The anti-tumor effect of combined treatment with arsenic trioxide and interferone-α on transplanted murine Lewis lung carcinoma
2005
Seo, D.L. (Gyeongsang National University, Jinju, Republic of Korea) | Lee, J.H. (Konkuk University, Seoul, Republic of Korea) | Yang, J.H. (Gyeongsang National University, Jinju, Republic of Korea) | Won, C.K. (Gyeongsang National University, Jinju, Republic of Korea) | Kim, M.O. (Gyeongsang National University, Jinju, Republic of Korea) | Kwark, S.D. (Gyeongsang National University, Jinju, Republic of Korea) | Koh, P.O. (Gyeongsang National University, Jinju, Republic of Korea), E-mail: pokoh@gsnu.ac.kr
In the present study, we expected the anti-tumor effect by combined treatment of arsenic trioxide and interferon (IFN)-α on murine Lewis lung carcinoma (LL2) cells through in vivo study. As a experimental model, LL2 cells (1×10∨6/mouse) were injected subcutaneously into the back region of mice. When the tumor volume reached 100 ㎣, mice were treated with 1 mg/kg arsenic trioxide, 50000 IU IFN-α, or arsenic trioxide and IFN-α. The development of tumor cells was significantly inhibited by combined treatment with arsenic trioxide and IFN-α. In arsenic trioxide and IFN-α treated group, apoptotic index was reached a peak valve at 48 hr after the treatment and it was restored to approximately the control level at 8 days.
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