Lack of connexin 32 does not enhance the benzene-induced hematotoxicity and hemopoietic tumor incidence in mice
2005
Yoon, B.I. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: byoon@kangwon.ac.kr
This study was performed to evaluate using wild-type (WT) and C×32 knockout (KO) mice if lack of cell to cell communication by connexin 32 gap junction enhances the benzene-induced hematotoxicity and hemopoietic tumor development. The WT and C×32 KO mice were exposed to 300 ppm of benzene for 6 hours/day, 5 days/week for a total of 26 weeks by inhalation, and then sacrificed to evaluate the toxicities of hemopoietic organs or allowed to live out their life span to evaluate the hemopoietic tumor incidence. The significant increase and decrease of organ weight were respectively noted in spleen and thymus of both WT and C×32 KO mice without significant difference between the genotypes.
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