Relationship between AgNORs and PCNA indices, histopathological appearance and clinical factors, as prognostic factor for canine oral melanoma
2004
Anudep Rungsipipat(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) | Siriwalee Ngow(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) | Nipaporn Pattanathaiyanon(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) | Porntipa Lertrattanachaikul(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology) | Khanchit Pongpech(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Dept. of Veterinary Surgery) | Chanin Kulprawit(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Dept. of Veterinary Surgery)
Purpose of this research was to evaluate the relationship between histopathological appearance and clinical data, Argyropphilic Nucleolar Organizer Regions (AgNORS) and Proliferative Cell Nuclear Antigen (PCNA) indices in canine oral melanoma. Retrospective study was performed on biopsy specimens from 67 dogs submitted over the years 2000 to 2003 to the Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University. Our results showed that the average AgNORs index did not show any significant differences with histopathological characteristics and Masson-Fontana Silver (MFS) stain but the AgNORs index showed significant differences when compared with histological grading and tumor diameter size (p LT 0.05). Average PCNA index did not show significant differences with histopathological characteristics, grading and MFS stain but did show significant differences with the sex of affected dogs and tumor diameter size (p LT 0.05). AgNORs and PCNA indices might be useful as a prognostic factor for oral melanoma in dogs.
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