Production of Chiral Epoxides: Epoxide Hydrolase-catalyzed Enantioselective Hydrolysis
2005
Choi, W.J. (Institute of Chemical and Engineering Sciences, Jurong Island, Singapore), E-mail: choi_won_jae@ices.a-star.edu.sg | Choi, C.Y. (Seoul National University, Seoul, Republic of Korea)
Chiral epoxides are highly valuable intermediates, used for the synthesis of pharmaceutical drugs and agrochemicals. They have broad scope of market demand because of their applications. A major challenge in modern organic chemistry is to generate such compounds in high yields, with high stereo- and regio-selectivities. Epoxide hydrolases (EH) are promising biocatalysts for the preparation of chiral epoxides and vicinal diols. They exhibit high enantioselectivity for their substrates, and can be effectively used in the resolution of racemic epoxides through enantioselective hydrolysis.
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