relative contribution of decreased insulin sensitivity to deterioration of glucose homeostasis
2008
Dimitrova, S. | Georgiev, I.
Insulin resistance IR is difined as a state of decreased ability of insulin to stimulate the uptake and metabolisin of glucose in target cells at physiological concentration. In men and cats IR usually precedes the development of type 2 diabetes mellitus. The most consistent sign of IR is the impaired glucose tolerance. The present review aims at going over the main points and analysing the available information about the role, nature, mechanisms and predisposing factors of IR as one of the primary factors for occurence of diabetes in men and cats. An emphasis is put on the elucidation of mechanisms of disturbances in obesity, that, along with decreased physical activity andadvanced age are among the essential risk factors of IR development. Hyperglycaemia, being one of the most important signs of IR is resulting from both inhibited uptake and metabolism of glucose in muscles and from its enhanced production in liver.
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