Hepatoprotective effects of milk thistle (Silybum marianum) seed cakes during the chicken broiler fattening
2008
Suchy, P.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Verejneho Veterinarniho Lekarstvi a Toxikologie | Strakova, E.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Vyzivy, Zootechniky a Zoohygieny | Kummer, V.,Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic) | Herzig, I.,Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic) | Pisarikova, V.,Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic) | Blechova, R.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Ustav Verejneho Veterinarniho Lekarstvi a Toxikologie | Maskova, J.,Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic)
The objective of this work was to verify the hepatoprotective effects of Silybum marianum seed cakes in feed mixtures used for the fattening of chicken broilers supplemented or not with chlortetracycline medication. The experiment was carried out on 180 ROSS 308 broiler chickens fed complete feed mixtures containing 0.0% (K), 0.2% (P1) and 1.0% (P2) of Silybum marianum seed cakes. The cakes used contained 2.95% of silymarin. On the 44th day of fattening half of the chickens from every group were supplied with chlortetracycline medicated water at a dose of 2 g/kg live weight. Cholesterol (Chol) levels and activities of glutamyl transferase (GMT), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were monitored. On the 52nd day of the test, six chickens from each group were euthanized and their liver was taken for histological examination. Adding Silybum marianum seed cakes resulted in a non-significant decrease in the chickens' live weight and in the feed conversion efficiency in both experimental groups. In comparison with control animals cholesterol levels were highly significantly lower on the 43rd day in group P2 and significantly lower on the 52nd day in group P1. ALT and AST activities were lower (p less than 0.01) in both experimental groups on the 22nd day of the experiment and AST activity was lower (p less than 0.01) on the 52nd day. In the chlortetracycline medicated group P2 cholesterol level (p less than 0.05) as well as ALT and AST activities decreased (p less than 0.01). Administration of silymarin reduced (p less than 0.01) the content of lipids and increased the content of glycogen in the liver of both experimental groups.
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