Alteration Of Hematological Indices During Experimentally Infection Of Rat With Toxoplasma Gondii (RH strain)
2006
Dalimi, A., Department of Parasitology, Medical Sciences Faculty, Tarbiat Modarres | Farhadi, A., Department of Parasitology, Medical Sciences Faculty, Tarbiat Modarres | Sharifian, M., Department of Parasitology, Medical Sciences Faculty, Tarbiat Modarres
Toxoplasmosis is a parasitic disease, which may change some laboratory indices in infected individuals. This study was conducted to determine hematological indices of blood of rats which experimentally infected witgondii. In this regard, 116 rats were divided into two groups of 87 test and 29 control groups. The test group inoculated intraperitoneally with 50000 tachyzoites. In the first 3 days of post infection, every 4 hours and then every 3 days for 60 days, three rats from test group and one rat from control group were bled. For hematological (CBC and platelet count) tests standard techniques were used. Results indicated that in infected rats the percentage of white blood cells was increased from 2nd to 4th and 7th to10th days of post infection. On the other hand, the percentage of neutrophil increased from 2nd to 5th days, while the percentage of lymphocyte was decreased up to 3 weeks. The percentage of eosinophil has not affected. Generally, during experimental infection of rat with toxoplasmosis temporary and nonspecific alteration of some hematological indices may occur. The alteration mainly is due to the parasite migration to the various tissues of the animal and it shift to the normal condition following cyst formation in brain or muscles.
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