Concentration-time profile of febantel in cultured tiger puffer Takifugu rubripes
2007
Kimura, T.(Kumamoto-ken. Government Office (Japan)) | Morita, J. | Nomura, Y. | Enomoto, J. | Mizoguchi, H. | Ishihara, M.
Febantel is a prodrug metabolized in vivo to fenbendazole which has been shown to be effective the against monogenean Heterobothrium okamotoi in cultured tiger puffer Takifugu rubripes. In this study, we investigated the relationship between the concentration-time profile of fenbendazole in the plasma and efficacy against H. okamotoi in tiger puffer following oral administration of febantel at the dose of 25 mg/kg 5 days. The concentration of fenbendazole was 4-5 micro g/g 2-4 days after first administration, and the number of parasites started to decrease from 3 days after the first administration. In addition, we measured the concentration of the remaining febantel and metabolites of fenbendazole in the muscle and skin in tiger puffer following oral administration at the dose of 50 mg/kg for 5 days. They were not detected 2 weeks after the last administration.
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