Establishment of ethanol-pretreating animal model to study Helicobacter pylori infection
2006
Lee, J.U. (Seoul National University, Seoul, Republic of Korea) | Kim, S.H. (Seoul National University, Seoul, Republic of Korea) | Park, T.W. (Wonkwang University, Iksan, Republic of Korea) | Kim, O.J. (Wonkwang University, Iksan, Republic of Korea), E-mail: kimoj@wonkwang.ac.kr
A stable and reliable Helicobacter pylori (H. pylori) infection animal model would be necessary for evaluating vaccine efficacy and helpful for understanding the pathological mechanism of the organism. The aim of the present study is to investigate the effect of ethanol treatment prior to H. pylori inoculation on associated gastric mucosal injury and to establish ethanol-pretreating animal model to study H. pylori infection. Male Mongolian gerbils were used for the study. H. pylori was orally inoculated after 12 h fasting.
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