Antibodies against Nitric Oxide Damaged Poly L-Tyrosine and 3-Nitrotyrosine Levels in Systemic Lupus Erythematosus
2006
Khan, Fozia (Faculty of Medicine, A.M.U. Aligarh, India) | Ali, Rashid (Faculty of Medicine, A.M.U. Aligarh, India), E-mail: raliamu@yahoo.com
Alterations in the amino acid structure or sequence can generate neo-epitopes from self-proteins causing autoaggressive immune attack. Reactive nitrogen species are an important factor that induces post-translational modification of proteins by cellular reduction and oxidation mechanism; cysteinyl-nitrosylation or tyrosine nitration leading to potentially pathogenic pathways. It was thought of interest to investigate the immunogenicity of nitrated poly L-tyrosine vis-a-vis its possible role in the induction of antibodies in systemic lupus erythematosus (SLE).
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