Effect of Glutathione S-Transferase Polymorphisms on the Antioxidant System
2007
Jeon, G.I. (Kyungnam University, Masan, Republic of Korea) | Park, E.J. (Kyungnam University, Masan, Republic of Korea), E-mail: [email protected]
Glutathione S-transferase genotypes GSTT1, GSTM1 and GSTP1 were characterized in 104 healthy male and female subjects and compared with parameters of oxidative stress at the level of DNA and lipids, with antioxidant enzymes, and with plasma antioxidants in smokers and non-smokers. Of the 104 subjects studied, 57.4% were GSTT1 present and 47.6% were GSTM1 present. The GSTP1 polymorphisms a and b were represented as follows: a/a, 75.5%; a/b, 21.6%; b/b type, 2.9%. The GSTT1 null genotype was associated with decreased glutathione in erythrocytes and elevated lymphocytes DNA damage.
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