Cutaneous asthenia associated with Ehlers-Danlos syndrome in a Yorkshire terrier
2007
Cho, S.J. (Family Animal Clinic, Gunsan, Republic of Korea) | Kim, O.J. (Wonkwang University, Iksan, Republic of Korea), E-mail: kimoj@wonkwang.ac.kr
Cutaneous asthenia or dematosparaxis is an uncommon, congenital and inherited connective tissue disease of dog and cat, resembling Ehlers-Danlos syndrome (EDS) in man. EDS is characterized by loose, hyperextensible and, fragile skin, it is attributed to mutations in connective tissue gene. These mutations cause defects in type Ⅰ or Ⅲ collagen synthesis and as a result lack of strength or elasticity to skin, joint, ligament and vessels. EDS-affected animals often experience subcutaneous hematomas that have long bleeding times.
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