Renal clearance and urinary excretion of ciprofloxacin in goats
2007
Iqbal, Z. (University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology) | Javed, I. (University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology) | Aslam, B. | Muhammad, F. | Jan, I.U.
The renal clearance and urinary excretion of ciprofloxacin were investigated in eight healthy female goats. In each animal, ciprofloxacin was administered intramuscularly at the rate of 5 mg/kg body weight. Following drug administration, blood and urine samples were collected at different time intervals and analyzed for ciprofloxacin and creatinine. High performance liquid chromatography (HPLC) was used to determine the drug concentration in the plasma and urine. The value of diuresis after single administration of ciprofloxacin was 0.073 plus minus 0.014 ml/min/kg. Mean (plus minus SE) values for renal clearance of creatinine and ciprofloxacin were 1.870 plus minus 0.385 and 0.982 plus minus 0.166 ml/min/kg, respectively. The ratio between the renal clearance of ciprofloxacin and that of creatinine remained less than one, which was indicative of back diffusion. The mean (plus minus SE) value for the cumulative percent of ciprofloxacin dose ex creted at 10 hours following its intramuscular administration was 13.03 plus minus 2.07. Based on these results, it was evident that besides glomerular filtration, renal handling of drug involved back diffusion also. It was concluded that in local goats glomerular filtration rate (GFR) was lower than that reported for their foreign counterparts.
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