Antibacterial activity of novel Pyrrolobenzodiazepines
2008
Benzeid, H. (University Mohamed, Rabat (Morocco). Dept. of Chemistry) | Chammache, M. (University Mohamed, Rabat (Morocco). Dept. of Chemistry) | Essassi, E.M. (University Mohamed, Rabat (Morocco). Dept. of Chemistry) | Imelouane, B. (National Inst. of Health, Agdal (Morocco)) | Ohmani, F. (National Inst. of Health, Agdal (Morocco)) | Charof, R. | Khedid, K.
The pyrrolobenzodiazepines (PBDs) constitute a class of pharmacological products recognized clinically for their effectiveness as much as antitumoral antibiotics. In present study; we report another pharmacological property as antibacterial activity of PBDs. Antibacterial tests were carried out on a range of gram positive and gram negative bacteria, which proved successful for the sulphurate PBD. The results of the minimal inhibiting concentration (MIC) varied from one bacterium to another. A great affinity of the PBD was found against Streptococcus and Salmonella species.
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