Effect of glutamate antagonists on nitric oxide production in rat brain following intrahippocampal injection
2007
Radenovic, L.,University of Belgrade, Belgrade (Serbia). Faculty of Biology, Institute of Physiology and Biochemistry | Selakovic, V.,Military Medical Academy, Belgrade (Serbia) | Janac, B.,Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Todorovic, D.,Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia)
The used glutamate antagonists APV (2-amino-5-phosphonopentanoic acid) and CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) both provided sufficient neuroprotection in the sense of reducing nitrate concentration, but with different mechanisms and time dynamics. Our findings suggest that NMDA (N-metyl-D-asparate) and AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate)/kainate receptors are differentially involved in nitric oxide production.
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