Human protein C production in the milk of F3 generation transgenic rabbits
2008
Chrenek, P., Research Institute of Animal Production, Nitra (Slovak Republic) | Dragin, S., Faculty of Agriculture, Novi Sad (Serbia) | Bozic, A., Faculty of Agriculture, Novi Sad (Serbia)
The stability of transgene transmission, milk production and milk content of recombinant human protein C (rhPC) in transgenic rabbits of F3 generation was determined. Transgenic rabbits carrying the 4.2 kb mouse whey acid protein promoters and 9.4 kb genomic human protein C were born after mating of transgenic (F2 generation) and non-transgenic rabbits. In conclusion the stability of hPC transgene transmission and production of rhPC protein C was confirmed in F3 generation of transgenic rabbits, with similar efficiency as in F1 and F2 generations, without reduction of milk production.
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