Effect of combined therapy of an anthelmintic and an immunomodulator on the elimination of gastrointestinal nematodes in sheep
2005
Varady, M.(Slovenska akademia vied, Kosice (Slovak Republic). Parazitologicky ustav | Konigova, A.Slovenska akademia vied, Kosice (Slovak Republic). Parazitologicky ustav | Cernanska, D.Slovenska akademia vied, Kosice (Slovak Republic). Parazitologicky ustav | Corba, J.Slovenska akademia vied, Kosice (Slovak Republic). Parazitologicky ustav)
The efficacy of the anthelmintic albendazole and the immunomodulator glucan on the elimination of gastrointestinal nematodes was investigated in naturally and experimentally infected sheep. The first experiment evaluated the effect of glucan against naturally acquired endoparasite infection. Sixty lambs were selected and divided into three experimental groups and an untreated control group, each with 20 or 10 animals. The anthelmintic used was albendazole. In all groups faecal egg counts (EPG) were performed at 1-month intervals. Results were assessed by comparing egg counts of the treated groups (albendazole, glucan, albendazole plus glucan) and the untreated control group. In the second experiment, the effect of glucan was investigated in experimentally infected groups of lambs (n=5) and worm counts of the treated and untreated group were compared. The administration of the immunomodulator showed no direct therapeutic effect, i.e. it did not reduce the level of gastrointestinal infection in both experiments. However, the combination with albendazole, in the first experiment, improved the efficacy and significant reduction in egg outputs were recorded from August to October in lambs on pastures compared to the group treated only with albendazole.
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