Retrospective review and systematic study of mammary tumors in dogs and characteristics of the extracellular matrix

English. The aim of the present study was to perform a retrospective review, from 1932 to 1999, in order to establish the number of cases of mammary tumors in dogs in the records at the Pathology Department of Faculdade de Medicina Veterinária - USP, as well as the presence of desmoplasia and cartilaginous and bone metaplasia in 578 of these tumors. Among the 537 malignant tumors, 13.05% were simple tubular adenocarcinomas, 3.91% were complex tubular adenocarcinomas, 7.26% simple papillary adenocarcinomas, 4.28% complex papillary adenocarcinomas , 23.27% simple papillary cystadenocarcinomas ,8.37% complex papillary cystadenocarcinomas,16.38% simple solid adenocarcinomas ,6.70% complex solid adenocarcinomas, 2.04% simple spindle cell carcinomas, 1.11% simple spindle cell carcinomas ,2.79% mucinous carcinomas ,8.19% anaplastic carcinomas ,0.93% squamous carcinomas, 1.30% fibrosarcomas,.0.18% chondrosarcoma, 0.18% osteosarcoma and among the 41 benign tumors ,51.21% were adenoma, 12.19% papillary cystadenoma,7.31% papilloma, 4.87% cystic fibroadenoma and 24.39% were fibroadenoma. Both desmoplasia and metaplasia were frequent findings in benign and malignant neoplasms, but they were more frequent among complex tubular adenocarcinomas: 38% presented desmoplasia, 57% cartilaginous metaplasia and 28% bone metaplasia. Among the benign neoplasms, adenoma presented the more frequency: 14 % presented desmoplasia, 29% cartilaginous metaplasia and 24% bone metaplasia. Results of this study emphasize the complexity of the inter-relationship between the macromolecules in the extracellular matrix and tumoral cells.

Portuguese. A finalidade do presente trabalho foi efetuar um estudo retrospectivo, de 1932 à 1999 , afim de se estabelecer a casuística desses tumores nos arquivos do Departamento de Patologia da Faculdade de Medicina Veterinária - USP , bem como a freqüência de desmoplasia, metaplasia cartilaginosa e óssea em 578 desses tumores. Entre os 537 tumores malignos, 13.05% foram adenocarcinomas tubulares simples, 3.91% foram adenocarcinomas tubulares compostos, 7.26% adenocarcinomas papilíferos simples, 4.28% adenocarcinomas papilíferos compostos, 23.27% cistoadenocarcinomas papilíferos simples, 8.37% cistoadenocarcinomas papilíferos compostos, 16.38% adenocarcinomas sólidos simples, 6.70% adenocarcinomas sólidos compostos, 2.04% carcinomas de células espinhosas simples, 1.11% carcinomas de células espinhosas compostos, 2.79% carcinomas mucinosos ,8.19% carcinomas anaplásicos ,0.93% carcinomas escamosos, 1.30% fibrossarcomas,.0.18% condrossarcoma, 0.18% osteossarcoma e entre os 41 tumores benignos ,51.21% foram adenomas, 12.19% cistadenomas pailíferos,7.31% papilomas, 4.87% fibroadenomas e 24.39% foram fibroadenomas. Tanto a desmoplasia como a metaplasia foi um achado freqüente nas neoplasias benignas e malignas, mas foram mais freqüentes entre os adenocarcinomas tubulares compostos: 38% apresentaram desmoplasia, 57% metaplasia cartilaginosa e 28% metaplasia óssea. Entre as neoplasias benignas, adenoma apresentou a maior frequência: 14 % com desmoplasia, 29% com metaplasia cartilaginosa e 24% com metaplasia óssea. Os resultados deste estudo enfatizam a complexidade da inter-relação entre as macromoléculas da matriz extracelular e as células tumorais.