A role of p-glycoprotein in modulation of antibiotic pharmacokinetics
2008
Haritova, A., Thracian University, Stara Zagora (Bulgaria)
P-glycoprotein (P-gp) belongs to superfamily of ABC (ATP-binding cassette) drug transporters. It is expressed in intestines, brain, kidneys, testes, liver, adrenal gland, lungs heart and eyes. This protein functions as a biological barrier by extruding toxic substances and xenobiotic out of cells. P-gp could modulate pharmacokinetics of antibacterial drugs through limitation of their oral absorption and penetration into target organs. Drug-drug interactions with antibacterials could be mediated by inhibition or induction of P-gp. Among the antibiotics recognized as substrates and modulators of P-gp are structurally unrelated compounds as fluoroquinilones, macrolides, ansamycines, tetracyclines and antracyclines. These findings provide a basis for the understanding of the pharmacokinetics, pharmacodynamics and toxicodynamics of the antibiotics in healthy and diseased individuals.
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