Ultrastructural studies on the presence of mycobacteria into cells of lungs and liver
2008
Kazachka, D., National Diagnostic and Research Veterinary Institute, Sofia (Bulgaria)
Macrophages are the key cells for invading end replication of mycobacteria in the host and they play principal role in the pathogenesis of the tuberculosis. The aim of the present study was to reveal if mycobacteria invade other cells except these of immune defense and macrophages first of all as a common feature. The results of ultrastructural studies of lungs of Mycobacterium bovis intraperitonealy infected rabbits and of livers of Mycobacterium avium subcutaneously infected chickens showed the presence of mycobacteria into the cytoplasm of pneumocyte II type and capillary endothelial cells of rabbit lungs as well as in the cytoplasm of chicken liver parenchima cells. On the base of these results it was suggested that the presence of surfactant or his components which enhance phagocytosis of mycobacteria by macrophages are the reason for mycobacteria affinity to invade pneumocyte II type as surfactant producers. Invading of pneumocytes II type as well as endothelial cells and hepatocytes is a part of the pathogenesis of the tuberculosis.
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