Pathology of Salmonella Abortus Equi infection in pregnant and non-pregnant Guinea pigs.
2004
Verma, M. | Paliwal, O. P. | Singh, B. R. | Sharma, A. K. | Tripathi, B. N., Indian Veterinary Research Institute, Izatnagar (India)
To study pathology of experimental Salmonella Abortus equi infection, 22 pregnant and equal number of non-pregnant guinea pigs were orally inoculated iwth S. Abortus equi strain (E-787) keeping 6 pregnant and equal number of non-pregnant animals as non-infected controls. Two animal each from infected pregnant and non-pregnant were sacrificed at 0,6,12 h and 1,2,3,4,5,10,15 and 21 days post inoculation to study the progression of pathological lesions. In pregnant animals lesions in colyledons progressed from congestion and haemorrrhage in initial stage to necrosis of trophoblastic cells, thrombosis and detachment of foetoplacental junctions. In non-pregnanat uterus. no specific gross or histopathological lesions were noticed. In other lymphoid cell hyperplasia followed by necrosis and depletion in spleen; congestion and dilatation of hepatic sinusoids and swelling of hepatocytes with scanty cytoplasm in liver. Based on the observations it can be concluded that thoug organisms systematized both in pregnant and non-pregnant animals but the major lesions were produced in cotyledons of pregnant animals indicating more susceptability of pregnant animals to infection.
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