Optimization and development of chamomil drop formulation
2007
Ghassemi Dehkordi, N., Department of Pharmacognosy and Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran | Aslani, A., Department of Pharmacognosy and Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran | Gordanpour, N.
More attention to consumption of herbal drugs are cost – effective and adverse effect of herbal drugs are may be lesser than chemical drugs. This formula chamomill drop is prescribed for prevention and treatment of peptic ulcer, gastritis and spastic condition of GI tract and also has significant antimicrobial effect. Despite its useful therapeutical properties, the prepared formula has a bitter taste so that it cause unaceptable for patients. After maturation , the obtained flower were dried. The amount of volatile oil existing in flower and amount of chamazulene and other effective components in plant were determined qualitatively and quantitively by the hydrodistillation method, UV/Vis spectrophotometry, TLC, GC/MS and also the dry plant weight percentage to its fresh weight were measured. Then 10% ethanol to make the extract with perculation procedure and solvent to flower ratio (8:1) choosed. Then by use of suitable sweetner and flavoring agent and with regard to maintance of characteristics and used dose in chamomille was tried to modulate chamomille's taste. Several formulations prepared and examined with sensation test and statistics test. The best formulation selected by volunteers as final formulation prepared with the extract and the amount of volatile oil, chamazulene and other effective components were measured. The best sweetner is saccharin sodium to prepared formulation and cherry flavor selected as the best flavoring agent to cover bitter taste of formulations. finally prepared formulation of matricaria extract contained 0.1% of cherry flavor and 1% sodium saccharin and 10% sucrose (for cover bitter taste) choosed as best formalation, that is also better and more acceptald statically than other formulations (p0/05).
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Agricultural Research and Education Organization