Production of monoclonal antibody against Bm86 and exploiting them as a tool for monitoring of similar structure/s in Hyalomma anatolicum anatolicum.
2006
Mir Jalili, A`li
Ticks are widely distributed around the world and they lead to more serious health problems for human and livestock. Lyme disease as well as Theileriosis and Babesiosis are amid major diseases transmitted by ticks to both human and animals respectively. Classical tick control through usage of chemicals may lead to emergence of resistance strains as well as poor animal productivity and environmental pollution. Immunological control by terms of vaccine against tick is developed within two recent decades. The known vaccine candidate moleculeBm86 has been widely used in commercial vaccines (Gavac and TickGARD) with great success. This concealed glycoprotein molecule poses a crucial role in midgut epithelial cells of Boophilus microplus which is the prevalent tick species in South America and Australia. In tropical and subtropical countries like IRAN, another tick species known as Hyalomma anatolicum anatolicum is the predominant tick species and preliminary studies with Gavac vaccine showed moderate success for its control. In this study we focused on finding other vaccine candidate molecules in Hyalomma anatolicum anatolicum by using monoclonal antibody against known vaccine moleculeBm86. The resulting monoclonal antibody (4E11) reacted with 36 and 45 kDa molecules of midgut epithelial cells of Hyalomma anatolicum anatolicum.
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