Concentrations of antioxidant vitamins in maternal and cord serum and their effect on birth outcomes
2009
Wang, Y.Z.(Third People's Hospital (China)) | Ren, W.H. | Liao, W.Q. | Zhang, G.Y.
Background: Emerging evidence indicates that maternal oxidative stress during pregnancy could impair fetal growth and that antioxidant vitamins (e.g. vitamins A, E and C) have a significant role in miantaining physiological processes of pregnancy and growth. Aims: To determine the concentrations of vitamins A, E, and C in pair-matched maternal and cord serum samples of neonate, and thus to investigate the relationship between maternal serum levels of these vitamins at delivery and birth outcomes. Methods: A total of 143 mother-neonate pairs were recruited into the cross-sectional descriptive study. Demographic information was investigated by questionnaire. After delivery, both cord and maternal blood were collected for quantification of serum levels of vitamins A, E and C by HPLC. Results: Maternal serum levels of vitamins A and E were significantly higher than those in cord serum. In contrast, vitamin C level in cord serum was significantly higher than that in maternal serum. Further, we found that maternal vitamin A status was significantly correlated to both birth weight (r=0.19, p=0.0419) and birth height (r=0.21, p=0.0311), and these were manifested by these findings: (i) per 250.2 g reduction in birth weight concomitant with 1 micromol/L increase in maternal serum vitamin A level (p0.01; 95% CI: 56.9-451.5); and (ii) per l% increase in the ratio of serum vitamin A level of neonate to mother concomitant with 0.8 cm increase in birth height (p
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